Pharmacokinetic Patterns of Sulfasalazine

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Abstract
First developed mistakenly for the treatment of rheumatoid arthritis, sulfasalazine salicylazosulfapyridine (SASP), along with cortico-steroids, constitutes the basic therapy for ulcerative colitis. The drug's pharmacokinetics, including its metabolism by the colonic flora, are discussed. In fact, it is concluded that the unabsorbed SASP serves to deliver the active components of SASP, 5-aminosalicylic acid and sulfapyridine, to the inflamed colon. The importance of acetylator phenotype and the necessity of checking for hemolysis and white cell function are mentioned.

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