THE ADMINISTRATION OF SODIUM GLUCURONATE TO JAUNDICED NEWBORN INFANTS

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Abstract
Sixteen cases of jaundice in the newborn period were treated with parenteral administration of sodium glucuronate. One case showed a decrease in concentration of indirect bilirubin in the serum, 2 cases showed a slight increase, and 13 cases showed no change during the entire observation period. Experimental evidence and clinical experience suggest that parenteral administration of sodium glucuronate does not enhance the formation of bilirubin glucuronide in the newborn infant. In the authors' experience, it has been an inefficient and unreliable method of reducing the concentration of indirect bilirubin in serum. In our opinion exchange transfusion is still the only recognized therapeutic procedure for decreasing indirect bilirubin in serum in the newborn infant.
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