Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase.
- 1 January 1976
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 29 (9) , 882-889
- https://doi.org/10.7164/antibiotics.29.882
Abstract
In the screening of catechol-O-methyltransferase inhibitors, 3 compounds were isolated from the culture filtrate of a mushroom, Inonotus sp. One was 3,4-dihydroxycinnamic acid (caffeic acid) which was reported as an inhibitor of this enzyme. The others were the d-2,6-bis-(3'',4''-dihydroxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione (dehydrodicaffeic acid dilactone) and its antipode. These new compounds inhibited both dopamine .beta.-hydroxylase and dopa decarboxylase and showed hypotensive activity in the spontaneously hypertensive rat.This publication has 5 references indexed in Scilit:
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