Prevention of Transfusion-Induced Chagas' Disease by Amphotericin B *
- 1 September 1980
- journal article
- research article
- Published by American Society of Tropical Medicine and Hygiene in The American Journal of Tropical Medicine and Hygiene
- Vol. 29 (5) , 761-765
- https://doi.org/10.4269/ajtmh.1980.29.761
Abstract
Amphotericin B, a polyene antibiotic effective against eukaryotic cells, can eliminate the trypomastigote form of Trypanosoma cruzi from blood stored at 4°C. This antitrypanosomal effect can be achieved with a concentration of 3 µg/ml within 48 hours. This concentration of amphotericin B does not produce hemolysis over a period of 3 weeks. Amphotericin B methyl ester and nystatin are not effective. Amphotericin B may be considered as a replacement for crystal violet in blood bank blood to prevent transfusion-induced Chagas' disease.This publication has 3 references indexed in Scilit:
- Classification of Polyene Antibiotics According to Chemical Structure and Biological EffectsAntimicrobial Agents and Chemotherapy, 1979
- Isolation of blood and intracellular forms ofTrypanosoma cruzifrom rats and other rodents and preliminary studies of their metabolismParasitology, 1978
- A Simple Monophasic Medium for Axenic Culture of HemoflagellatesJournal of Parasitology, 1976