CLINICAL USE OF NEW TYPES OF MODIFIED PROTAMINE ZINC INSULIN

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Abstract
Observations on 16 diabetic patients with long-standing and essentially stable disease convince us that the special modified protamine zinc insulin of Mac Bryde and Roberts is the best type of protamine insulin for most diabetics who require 40 or more units daily. One patient found the modified insulin relatively inactive and was unwilling to make a further trial since beginning acidosis occurred. This experience was not duplicated on any other occasion. One other patient felt that an extemporaneous mixture (5:3) was superior to the specially modified insulin. In all other cases, the treatment with a single daily injn. of MPZ insulin was preferable to any other routine tried.