Therapeutic Effect of Thiabendazole on Angiostrongylus cantonensis Infections in Rats

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Abstract
Thiabendazole was highly effective in controlling the early invasive stages of the rat lungworm, A. cantonensis. The feeding of diets containing 0.1% thiabendazole to lungworm-exposed rats for 7, 14, or 21 days, beginning on the day of exposure to infection, almost completely inhibited the development of lungworms. The worms appeared least susceptible to thiabendazole during the 3rd week of their development in the rat. When the parasites were 4 to 6 weeks of age, they were again vulnerable to the anthelmin-tic action of thiabendazole. Dose-response relationships were observed when oral dosages of thiabendazole were administered to lungworm-infected rats. Depending upon the dosage, time, and duration of medication, the worms were killed, their migration to the lungs was delayed, or their oviposition was prevented. Since these worms appear particularly susceptible while migrating to and in the brain of rats, thia-bendazole should be considered for possible therapy of parasitic meningoencephalitis in man.

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