Total synthesis of human cholecystokinin-33
- 1 January 1988
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 4,p. 324-325
- https://doi.org/10.1039/c39880000324
Abstract
Human cholecystokinin (hCCK-33) has been synthesized by selective esterification of the Tyr-phenolic OH group (position 27) of unsulphated hCCK-33 with pyridine–SO3 complex after reversible masking of other functional groups by hard base (F–)-labile protecting groups: amino functions by the fluoren-9-ylmethoxycarbonyl group and the Ser-OH group by the t-butyldiphenylsilyl group.Keywords
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