Diuretic-Based Treatment and Cardiovascular Events in Patients With Mild Renal Dysfunction Enrolled in the Systolic Hypertension in the Elderly Program
Open Access
- 22 June 1998
- journal article
- clinical trial
- Published by American Medical Association (AMA) in Archives of internal medicine (1960)
- Vol. 158 (12) , 1340-1345
- https://doi.org/10.1001/archinte.158.12.1340
Abstract
INCREASED SERUM creatinine levels, a marker of renal dysfunction, are an independent predictor of cardiovascular events such as stroke and coronary artery events. Hypertension can accelerate renal dysfunction, and renal dysfunction can cause or worsen hypertension. Both increase the risk of cardiovascular complications.1 In about 1 of 3 patients with hypertension, renal dysfunction develops that is characterized by abnormal serum creatinine levels,2 and hypertension is a major cause of renal failure, second only to diabetes mellitus.3This publication has 6 references indexed in Scilit:
- Effect of diuretic-based antihypertensive treatment on cardiovascular disease risk in older diabetic patients with isolated systolic hypertension. Systolic Hypertension in the Elderly Program Cooperative Research GroupPublished by American Medical Association (AMA) ,1996
- Effect of the Angiotensin-Converting–Enzyme Inhibitor Benazepril on the Progression of Chronic Renal InsufficiencyNew England Journal of Medicine, 1996
- Blood Pressure and End-Stage Renal Disease in MenNew England Journal of Medicine, 1996
- Comparative Study of the Effect of ACE-Inhibitors and Other Antihypertensive Agents on Proteinuria in Diabetic PatientsAmerican Journal of Hypertension, 1994
- Diuretic Therapy for Hypertension and the Risk of Primary Cardiac ArrestNew England Journal of Medicine, 1994
- Prevention of stroke by antihypertensive drug treatment in older persons with isolated systolic hypertension. Final results of the Systolic Hypertension in the Elderly Program (SHEP). SHEP Cooperative Research GroupJAMA, 1991