EFFECT OF HYPOPHYSIAL STALK SECTION ON ADENOHYPOPHYSIAL FUNCTION*

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Abstract
The effect of hypophyseal stalk section on adenohypophyseal function was studied in guinea pigs. Complete stalk section was indicated by occurrence of diabetes insipidus in all operated animals. Complete stalk section was also often verified by histological examination of the stalk and the supraoptic nuclei. Secretion of adrenocorticotropin (ACTH) in response to cold was tested by measuring adrenal cholesterol content. Body weight and gonad weight and histology provided information on the secretion of growth hormone and gonadotropins. The results indicated that secretion of ACTH, growth hormone and gonadotropins does not depend on an intact hypophyseal stalk.