The Effect of Spreading Cortical Depression on Activity of Subcortical Relay Nuclei of Specific Afferent Pathways

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Abstract
In unanaesthetised-curarised (2 mg./kg. i.p.) rats and in animals narcotised with Dial (40-50 mg./kg.) the authors studied primary responses in subcortical relay nuclei of specific afferent pathways in acute experiments during unilateral or bilateral cortical spreading depression which represents functional decortication. Primary responses to acoustic stimuli in the colliculus caudalis and corpus geniculatum mediale, the light flashes in the colliculus rostralis and corpus geniculatum laterale and to stimulation of the sciatic nerve in the mesencephalon (lemniscus) and ventral thalamic nucleus do not change during reversible functional neocortical ablation. These results indicate that there is a difference between specific and nonspecific structures probably with regards to cortical control of their activity.

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