THE TOXIC EFFECTS OF DEFIBRINATED BLOOD WHEN PERFUSED THROUGH THE ISOLATED MAMMALIAN HEART

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Abstract
While the mammalian heart will beat for hours when perfused with pure oxygenated Locke''s solution, the addition of the animal''s defibrinated blood to the perfusion fluid is poisonous to the heart. Such blood may be detoxified by repeated passage through the lungs (confirming the work of Starling and Verney). The substance responsible for this action on the heart causes a marked and prolonged drop in blood pressure. Several theoretic considerations are raised about the possible role of this substance in biologic phenomena.

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