Hypothalamo-pituitary hormone insufficiency associated with cleft lip and palate.
- 1 December 1978
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 53 (12) , 952-955
- https://doi.org/10.1136/adc.53.12.952
Abstract
Two male patients with congenital cleft lip and palate first seen at ages 10.2 and 21.5 yr presented with typical signs of hypothalamic-anterior pituitary hormone deficiencies. They lacked GH [growth hormone], LH [lutropin], and FSH [follitropin] and were partially deficient in TSH [thyrotropin] and ACTH. Several congenital defects may explain this rare syndrome affecting midline structures in the proximity of the maldeveloped palate, including Rathke''s pouch, which migrates distally to develop into the anterior pituitary.This publication has 11 references indexed in Scilit:
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