The Effect of Catecholamines on the Pars Intermedia Autotransplanted into the Anterior Chamber of the Eye of the Frog, Rana Nigromaculata

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Abstract
Intense, long-lasting darkening of theskin color of the frog, Rana nigromaculata, was demonstrated by autotransplantation of the pars neurointermedia into the anterior chamber of the left eye. At 4 months post-operative, catecholamines were injected into the eye. It was found that: (1) catecholamines produce a marked bleaching effect when injected into the left eye containing the transplant; (2) catecholamines show a very weak and short bleaching effect when injected into the intact, right eye; (3) no bleaching effect is observed when a solvent of catecholamines is injected into the right and left eyes; and (4) in the transplanted pars intermedia, the droplets of acidophilic colloid increase in number and accumulate in the vicinity of the blood capillaries within the gland and of those adjacent to the pars nervosa. These droplets decrease remarkably after the injection of catecholamines into the left eye with the transplant. These findings led to the conclusion that catecholamines have a direct effect on the pars intermedia, blocking the release of MSH from the gland cells, thus resulting in a pallor of the skin color.

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