Synthesen in der Polymyxin‐Reihe 2. Mitteilung. Synthese eines Dipeptid‐Fragmentes mit (+)‐Isopelargonsäure
- 1 January 1960
- journal article
- research article
- Published by Wiley in Helvetica Chimica Acta
- Vol. 43 (1) , 279-286
- https://doi.org/10.1002/hlca.19600430137
Abstract
(+)‐6‐Methyloctanoic (isopelargonic) acid, the fatty acid component of certain polypeptide antibiotics known as polymyxins, has been synthesized by a new route, starting from (−)‐2‐methylbutanol‐(1). The protected dipeptide Nα‐(+)‐Isopelargonyl‐Nγ‐benzyloxycarbonyl‐D‐α,γ‐diaminobutyryl‐L‐threonine, corresponding to the side chain of two structures which have been proposed for polymyxin B1, was obtained by known peptide coupling methods.This publication has 7 references indexed in Scilit:
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