THE EFFECT OF l-THYROXINE ON SERUM LIPOPROTEIN AND CHOLESTEROL CONCENTRATIONS*

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Abstract
The effect of intravenous administration of 6 mg. per week of l-thyroxine for a period of sixteen weeks on low-density and high-density serum lipoproteins, total serum cholesterol, body weight, pulse and blood pressure was studied in a group of 13 institutionalized ambulatory schizophrenic patients. Sf[degree]-12 and Sf[degree]12-20 serum lipoprotein concentrations were significantly reduced, but no effect on Sf[degree]20-100 and Sf[degree]1OO-400 was observed. Total serum cholesterol as well as high-density serum lipoprotein concentrations were also significantly reduced. The reduction in low-density serum lipoprotein concentrations was found to be highly correlated with initial (pre-treatment) levels, resulting in greater decreases in serum lipoprotein concentrations the higher the initial level. Body weight and diastolic blood pressure decreased significantly and pulse rate increased. l-Thyroxine is an effective hypolipoproteinemic substance, producing a pattern of changes in serum lipoprotein and total serum cholesterol similar to that previously reported with desiccated thyroid.

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