Production of Coproantibodies and Immune Complexes in Piglets Infected with Rotavirus

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Abstract
The local immune response of newborn piglets to experimental infection with rotavirus was analyzed by means of coproantibodies, immune complexes, and the detection of rotavirus. Immune complexes appeared in the feces on day 4 after inoculation when the production of rotavirus began to decrease; they reached a peak when no rotavirus could be detected in the feces. The presence of free IgA and IgM antibodies to rotavirus could be demonstrated on day 7 when the immune complexes had already reached a maximum level. An enzyme-linked immunosorbent assay was used for all of the analyses.