Induction of Pituitary Lactotrope Differentiation by Luteinizing Hormone α Subunit
- 2 November 1984
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 226 (4674) , 566-568
- https://doi.org/10.1126/science.6208610
Abstract
Addition of gonadotropin releasing hormone to cultures of fetal rat pituitary induced differentiation of lactotropes as revealed by immunocytochemistry. Antiserum to luteinizing hormone (LH) (recognizing native LH), but not antiserum to LH-beta (recognizing both native LH and its beta subunit), inhibited this induction. Further addition of highly purified LH-alpha subunit in culture medium also induced lactotrope differentiation. Thus, the alpha subunit may have a specific biological activity of its own with probable practical use in clinical investigations.Keywords
This publication has 22 references indexed in Scilit:
- Evolution of Lactotropes in Normal and Anencephalic Human Fetuses*Journal of Clinical Endocrinology & Metabolism, 1984
- Cryoultramicrotomy versus plastic embedding: comparative immunocytochemistry of rat anterior pituitary cellsJournal of Microscopy, 1983
- α-Subunit and Gonadotropin Responses to Luteinizing Hormone-Releasing Hormone in Hyperprolactinemic Women before and after Bromocriptine*Journal of Clinical Endocrinology & Metabolism, 1983
- Comparative Study in vivo and in vitro of the Differentiation of Immunoreactive Gonadotropic Cells in Fetal Rat Anterior PituitaryNeuroendocrinology, 1983
- Glycoprotein hormone α-subunit secretion in patients with pituitary adenomas: influence of TRH, LRH and bromocriptineActa Endocrinologica, 1982
- Immunocytological Determination of Gonadotropic and Thyrotropic Cells in Fetal Rat Anterior Pituitary during Normal Development and under Experimental ConditionsNeuroendocrinology, 1981
- Synthesis and release of gonadotropins and their subunits by long-term organ cultures of human fetal hypophysesMolecular and Cellular Endocrinology, 1977
- RELEASING FACTOR AND HORMONAL CHANGES IN THE HYPOTHALAMIC-PITUITARY-GONADOTROPHIN AND -ADRENOCORTICOTROPHIN SYSTEMS BEFORE AND AFTER BIRTH AND PUBERTY IN MALE, FEMALE AND ANDROGENIZED FEMALE RATSJournal of Endocrinology, 1977
- IDENTIFICATION OF HUMAN LUTEINIZING HORMONE, FOLLICLE-STIMULATING HORMONE, LUTEINIZING HORMONE β-SUBUNIT AND GONADOTROPHIN α-SUBUNIT IN FOETAL AND ADULT PITUITARY GLANDSJournal of Endocrinology, 1975
- Porcine Luteinizing Hormone and its SubunitsEuropean Journal of Biochemistry, 1971