Fluid Shear Stress Modulation of Gene Expression in Endothelial Cells
- 1 October 1998
- journal article
- research article
- Published by American Physiological Society in Physiology
- Vol. 13 (5) , 241-246
- https://doi.org/10.1152/physiologyonline.1998.13.5.241
Abstract
The vascular endothelium, lining the blood vessel wall, is constantly exposed to wall shear stresses generated by flowing blood. Gene regulation, critical for endothelial cell function, depends on complex interactions at the promoter level and utilizes overlapping signal transduction cascades to activate the expression of genes involved in many biological processes.Keywords
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