The Ceroid Nature of the So-called “Hamazaki-Wesenberg Bodies.”

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Abstract
Round, ovoid, and angular bodies measuring L to 15 μ were observed in macrophages as well as lying free in peripheral portions of lymph nodes from patients with sarcoidosis, in hyperplastic regional lymph nodes of patients with carcinoma of the head and neck, and in an example of isolated lymphoid tumor. The results of tinctorial reactions and electron microscopy indicate that these particles, designated in the literature as “Hamazaki-Wesenberg bodies,” are a form of ceroid and lack features of bacteria or other infectious agents. This identification of the nature of Hamazaki-Wesenberg bodies refutes claims that they are bacterial agents that may be etiologically significant or pathognomonic for sarcoidosis. The significance of the ceroid deposits in these nodal lesions, as well as in many other pathologic situations in man in which such pigment is found, is at present unknown.

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