Human sperm chromosome studies in a reciprocal translocation t(2;5)
- 1 May 1988
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 79 (1) , 24-28
- https://doi.org/10.1007/bf00291704
Abstract
Sperm chromosome complements have been studied in a man heterozygous for a reciprocal translocation t(2;5)(p11;q15). Human sperm chromosomes were obtained after fertilization of zona-free hamster eggs. A total of 75 human sperm metaphases were analysed. Of the complements studied, 59 (78.6%) resulted from a 2:2 segregation and 16 (21.3%) from a 3:1 segregation, 4:0 segregation was not observed. Our results indicate that at least 36% of sperm complements were unbalanced with respect to the translocation. The frequency of other chromosome anomalies unrelated to the translocation was 16%.Keywords
This publication has 20 references indexed in Scilit:
- G-banding of human sperm chromosomesHuman Genetics, 1986
- A human 9;20 reciprocal translocation associated with male infertility analyzed at prophase and metaphase I of meiosisCytogenetic and Genome Research, 1986
- Human sperm chromosomes obtained from hamster eggs after sperm capacitation in TEST‐yolk bufferGamete Research, 1985
- Chromosome segregation into the spermatozoa of two men heterozygous for different reciprocal translocationsHuman Genetics, 1983
- A detailed method for obtaining preparations of human sperm chromosomesCytogenetic and Genome Research, 1983
- Meiotic behaviour of two human reciprocal translocations.Journal of Medical Genetics, 1981
- Factors predisposing to adjacent 2 and 3:1 disjunctions: study of 161 human reciprocal translocations.Journal of Medical Genetics, 1979
- Familial balanced translocation 4p+/17q- as a suggested cause of primary trisomy-21 Down's syndrome.Archives of Disease in Childhood, 1977
- Meiotic behavior of five human reciprocal translocationsCytogenetic and Genome Research, 1976
- Reciprocal translocations in man. 3:1 Meiotic disjunction resulting in 47- or 45-chromosome offspring.Journal of Medical Genetics, 1975