L-Arginine Increases Exercise-Induced Vasodilation of the Forearm in Patients With Heart Failure

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Abstract
To determine whether L-arginine, a precursor of nitric oxide, can improve exercise-induced vasodilation of the forearm in patients with heart failure, we measured forearm blood flow in 9 patients with heart failure and in 7 age-matched control subjects before and after intra-arterial infusion of L-arginine. Resting forearm blood flow was significantly lower in patients with heart failure than in control subjects (2.34±0.85 (SD) vs 4.76±0.77 ml/min per 100 ml, pJpn Circ J 1997; 61: 471 - 480)