Dynamic Studies on the Inorganic Iodine Compartment and Its Exchanges During Adolescence

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Abstract
Dynamic studies of the inorganic iodine compartment have been performed in 26 children between the ages of 9 and 15 years. Significant findings include the following: 1) The mean plasma inorganic iodine (PII) is 0.11 μg/100 ml by the renal clearance method and 0.13 by calculation from the specific activities. 2) The renal iodine clearance, expressed per unit of weight or square meter, is elevated. 3) The iodide pump is hyperactive. The absolute iodine uptake is 40 μg/day. No correlation has been found between the PII and the renal clearance. There is a negative correlation between the PII and the level of activity of the iodide pump, although the adjustment of the activity to the PII is not complete. It is concluded that, during adolescence, there is increased renal iodide clearance and hyperactivity of the thyroid. As a corollary of this increased turnover rate of iodine, it could be predicted that the iodine requirement during adolescence is greater than in the adult, and iodine deficiency would be expected more frequently. These are important for the understanding of the mechanisms underlying the frequent enlargement of the thyroid during adolescence and puberty.

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