RNA Editing AIDs Antibody Diversification?
- 8 September 2000
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 289 (5485) , 1705-1706
- https://doi.org/10.1126/science.289.5485.1705
Abstract
How do B cells generate the enormous diversity of antibodies that are able to recognize and bind to whichever antigen a B cell might happen to encounter in the body? Several genetic mechanisms that manipulate different combinations of immunoglobulin genes are known. In their Perspective, Neuberger and Scott, highlight another genetic mechanism called RNA editing now shown to be involved in the production of antibody diversity.Keywords
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