A Convenient Synthesis and Resolution of R- and S- Atrolactic Acid in High Enantiomeric Purity
- 1 January 1976
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 6 (8) , 601-608
- https://doi.org/10.1080/00397917608063555
Abstract
Although chiral atrolactic acid has been the subject of extensive studies by Prelog1 and others,2 there is no simple method to obtain either enantiomer in high purity. During the course of an investigation designed to assess the utility of chiral oxazolines3 as vehicles for asymmetric syntheses, we encountered an efficient technique to obtain either R or S atrolactic acid 4 from a single chiral precursor.Keywords
This publication has 4 references indexed in Scilit:
- The Synthetic Utility of 2‐OxazolinesAngewandte Chemie International Edition in English, 1976
- Asymmetric synthesis of R and S .alpha.-alkylalkanoic acids from metalation and alkylation of chiral 2-oxazolinesJournal of the American Chemical Society, 1976
- Oxazolines. IX. Synthesis of homologated acetic acids and estersThe Journal of Organic Chemistry, 1974
- Untersuchungen über asymmetrische Synthesen I. Über den sterischen Verlauf der Reaktion von α‐Ketosäure‐estern optisch aktiver Alkohole mit Grignard'schen VerbindungenHelvetica Chimica Acta, 1953