Studies on Some Crystalline Forms of Ibuprofen

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Abstract
Different crystal forms of ibuprofen were prepared and characterized by IR spectra, melting point, morphological structure, dissolution studies, and stability. Different forms were found to demonstrate variable physicochemical properties and dissolution rates. These ranged in physical appearance from prisms to needles and plates. The dissolution t70 ranged from 48 minutes to > 480 minutes. The stability study indicated that most of the crystal forms were stable at room temperature, and also at 60® C over one month.