Microencapsulation and bioavailability in beagle dogs of indomethacin.

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Abstract
Indomethacin (IMC) suspended in soybean oil was microencapsulated in a gelatin-acacia system by a modified phase separation method from aqueous solution. The microcapsules were hardened with formaldehyde without the use of NaOH. Average particle diameter of the microcapsules was 111 .mu.m, and the content of IMC in the microcapsules was > 80% of the initial amount of IMC. The in vitro dissolution of IMC from the microcapsules was slower than that of intact IMC, and this indicated that the walls of the microcapsules affected the drug dissolution. The bioavailabilities in beagle dogs of the IMC microcapsules and of a soybean oil suspension of IMC administered in capsules were larger than that of intact IMC.

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