UNUSUAL INTRANUCLEAR FILAMENTS IN CIRCULATING LYMPHOCYTES OF PATIENTS WITH MULTIPLE-SCLEROSIS AND OPTIC NEURITIS
- 1 January 1976
- journal article
- research article
- Vol. 83 (2) , 245-254
Abstract
Mononuclear cells obtained from the peripheral blood of patients with multiple sclerosis (MS) and optic neuritis (ON) were examined by EM. Unusual intranuclear filaments identical with the so-called paramyxovirus-like filaments were found in circulating lymphocytes from 5 patients with MS and 3 with ON. They were observed in 0.1-0.5% of the mononuclear cells. EM of the blood cells from 5 other patients with ON, 3 patients with neurologic diseases other than MS, and 4 normal subjects failed to reveal similar structures. The filaments were also absent from blood cells from normal subjects during the process of autolysis.This publication has 19 references indexed in Scilit:
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