FACTORS INFLUENCING RESPONSE OF ESCHERICHIA-COLI TO ANTIBIOTICS IN CONDITIONS PREVAILING IN INFECTED URINARY-BLADDER

  • 1 January 1976
    • journal article
    • research article
    • Vol. 57  (3) , 303-309
Abstract
The response of a sensitive strain of E. coli to a variety of antibiotics was examined in an in vitro model which simulates the hydrokinetic features of the urinary bladder. Recovery of bacterial cultures from antibiotic effects was observed following exposure to bactericidal and bacteriostatic antibiotics and no substantial difference was noted between the effectiveness of bacteriostatic and bactericidal agents except that bacteriostatic antibiotics were more influenced by alteration of the conditions of diuresis and frequency of micturition. The response of dense bacterial populations to high concentrations of 3 .beta.-lactam antibiotics varied markedly under the different hydrokinetic conditions. Possible reasons for these variations are discussed.