Growth of Neurotropic Viruses in Extraneural Tissues

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Abstract
Summary and Conclusions: Cynomolgus and rhesus monkeys, mice, hamsters, guinea pigs, rabbits and dogs were inoculated intratesticularly with two strains of poliomyelitis virus, Hof of type I and Lansing of type II. Tests at 7, 10 and 14 days gave no evidence of multiplication of virus at the site of inoculation. In a second experiment inoculation of testes of cynomolgus monkeys was accomplished by placing virus in an area in which testicular tissue had been minced in situ, to expose cells inside tubules. Tests for virus at 3, 6, 7 and 10 days did not show increase of virus in local tissue. It is concluded that negative findings in these experiments do not constitute substantial evidence against the concept of extraneural multiplication of poliomyelitis virus in natural infection and that this remains an unsettled problem. The striking contrast between rapid and abundant growth of poliomyelitis virus in suitable testicular tissue cultures and failure of the virus to multiply in injected testes in the present experiments remain unexplained.

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