Studies on T4 Lysozyme

Abstract
T4 lysozyme has been purified to apparent homogeneity from lysates of T4‐infected Escherichia coli B cells. In the purification procedure advantage was taken of the affinity of the enzyme for chitin. Binding of the enzyme to chitin under suitable conditions was found to be very efficient and complete, depending on the pH and ionic strength of the medium. The conditions for adsorption and desorption are different from those of hen egg‐white lysozyme. The enzyme could be desorbed from the chitin columns by increasing the ionic strength at a low pH.