Bromocriptine in Parkinson's disease: a study of cardiovascular effects.

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Abstract
Blood pressure and pulse rate were studied in 20 Parkinsonian patients on no treatment and during treatment with bromocriptine (mean dosage 148 mg/day) as the sole anti-Parkinsonian therapy. The drug reduced erect systolic and diastolic and supine systolic blood pressure and increased erect pulse rate, in a predictable dose-dependent manner. The occurrence of episodes of significant postural hypotension was less predictable and was a transitory phenomenon in all patients. Peripheral receptor blockade with domperidone did not alter the findings, suggesting that the principal mechanism for these cardiovascular effects is a central dopaminergic one.