Origin in Tobacco Smoke of N ′-Nitrosonornicotine, a Tobacco-Specific Carcinogen: Brief Communication 2 3

Abstract
To evaluate risk factors and to approach methods of reduction of the carcinogenic potential of cigarette smoke, the transfer rate of N-nitrosonornicotine in a popular U.S. blended cigarette into mainstream smoke was quantitatively determined. The mean transfer rate was 11.3%; thus ≈46% of the tobacco-specific carcinogen in the smoke came from the tobacco, and the remainder was synthesized during smoking.

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