Incidence, Latency, and Morphologic Types of Neoplasms Induced by Simian Virus 40 Inoculated Intravenously Into Hamsters of Three Inbred Strains and One Outbred Stock2

Publisher Website
Google Scholar
Abstract
The incidence, latency, and morphologic types of neoplasms induced in hamsters of the three inbred strains LSH/-SsLak, LHC/Lak, and MHA/SsLak, inoculated iv at 3 weeks of age with 107.5 median tissue culture infective dose (TCID50) of simian virus 40 (SV40), were determined and compared with those of the outbred stock LVG/Lak. Although the incidence and latency were approximately the same in hamsters of the three inbred strains, hamsters of the outbred stock exhibited almost complete resistance to tumor induction under identical experimental conditions. The morphologic types of neoplasms, i.e., lymphocytic leukemia, reticulum cell sarcoma, osteogenic sarcoma, and anaplastic sarcoma, induced in inbred hamsters were similar to those induced in outbred hamsters inoculated iv with 108.5 TCID50 SV40. The lymphocytic leukemias that developed in the 2 LSH/SsLak ibred hamsters were established as tumor transplants in vivo and as permanent cell lines in vitro.