New inhibitors of melanogenesis, OH-3984 K1 and K2. II. Physico-chemical properties and structural elucidation.

1 January 1993

journal article
Published by Japan Antibiotics Research Association in The Journal of Antibiotics

Vol. 46 (10) , 1526-1529
https://doi.org/10.7164/antibiotics.46.1526

Abstract

New melanin synthesis inhibitors, OH-3984 K1 and K2, were isolated from the fermentation broth of Streptomyces sp. OH-3984, and their structures were elucidated by spectroscopic methods and by chemical transformations. OH-3984 K1 (M.W.: 306; C18H26O4) and K2 (M.W.: 308; C18H28O4) have unique gamma-lactone rings, both of which correspond to oxidative products derived from C1-O14 cleavage of the 14-membered lactone group.

Keywords

STRUCTURAL
M.W
CORRESPOND
STREPTOMYCES
CLEAVAGE
C18H26O4
BROTH

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