Motor Activity in Schizophrenia

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Abstract
Introduction In a number of previous reports1-3 data have been presented showing that when chicken erythrocytes are incubated in plasma from patients with schizophrenia the ratio of lactate to pyruvate remaining in the medium is significantly higher than the ratio obtained using plasma from control subjects. On the average, patients' plasma gives a ratio approximately twice as great as the ratio derived from the study of control subjects. This difference in lactate/pyruvate (L/P) ratio between control and schizophrenic plasma is apparently caused by a substance in plasma, probably a protein.3,4 At present this substance has not been completely identified, so that it is unknown whether it is a normal substance in excessive amount, or an abnormal one. While the chicken cell method differentiates between groups of schizophrenic and nonschizophrenic subjects, there is overlap in the distributions of the L/P ratios between the two groups.

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