Mechanism of Action of Vitamin K: Demonstration of a Liver Precursor of Prothrombin
- 12 January 1973
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 179 (4069) , 192-194
- https://doi.org/10.1126/science.179.4069.192
Abstract
Extracts of sonicated liver microsomes that are prepared from rats deficient in vitamin K or from rats given vitamin K antagonists contain a factor that liberates a thrombin-like activity when it is incubated with venom from Echis carinatus. The amount of this factor is low in control rats and in hypoprothrombinemic rats given vitamin K 1 hour before they were killed. These data indicate that this factor is a protein precursor of prothrombin, which is synthesized in the liver.Keywords
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