Secretion of Primary Granules from Developing Human Eosinophilic Promyelocytes

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Abstract
The primary large homogenous dense granules of eosinophilic promyelocytes [from patients with chronic myelocytic leukemia metastatic adenocarcinoma and idiopathic thrombocytopenic purpura] were apparently released into the extracellular space of the marrow by exocytosis while the cell was producing new secretory granules. This process apparently occurred in 2 steps: initial fusion of several individual granules to form one large myeloperoxidase positive membrane-delimited body, followed by exocytotic release of the granule content. The membrane of this large secretory granule appeared to be retained within the cell since empty, myeloperoxidase positive vacuolar structures remained following secretion.