Cholinergic and beta-adrenergic compounds in the control of drinking behavior in the rat.

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Abstract
Describes a series of studies with male Wistar rats (N = 220) in which injections of a- and b-adrenergic agonists and antagonists, as well as carbachol and angiotensin II amide, were either (a) made into the lateral hypothalamus through permanently implanted cannulas or (b) administered subcutaneously to observe drinking and eating behavior. In contrast to previous reports, intrahypothalamic injections of the b-adrenergic agonist isoprenaline hydrochloride failed to elicit drinking behavior. Both carbachol and angiotensin administered to the same site and subcutaneously-administered isoprenaline induced drinking behavior. Intrahypothalamic injections of isoprenaline reduced both deprivation-induced thirst and hunger. Prior injection of the b-adrenergic blocker propranolol hydrochloride eliminated the blocking effect of isoprenaline on hunger but not thirst. Drinking induced by intrahypothalamic injections of carbachol was reduced by prior injection of isoprenaline. It is concluded that isoprenaline administered intrahypothalamically has an inhibitory effect on both hunger and thirst. (24 ref) (PsycINFO Database Record (c) 2006 APA, all rights reserved)

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