Review of analytical methods used in the dissolution testing of pharmaceuticals

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Abstract
The in vitro dissolution test is the most useful quality control test for pharmaceutical dosage forms such as tablets and capsules from the standpoint of bioavailability and physical consistency. Because bioavailability is largely dependent upon having the drug in dissolved state, for poorly soluble drugs the dissolution test can give an indication of poor bioavailability and reduced efficacy. In dissolution testing modern analytical techniques play an important part. This paper provides an overview of the analytical techniques used in dissolution testing and assesses their advantages and disadvantages.

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