FAMILIAL FACTORS IN PREMATURE CORONARY HEART DISEASE—A PRELIMINARY REPORT FROM THE TECUMSEH COMMUNITY HEALTH STUDY1

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Abstract
Deutscher, S., L D. Ostrander and F. H. Epstein (Univ. of Michigan School of Public Health, Ann Arbor, Mich. 48104). Familial factors in premature coronary heart disease—a preliminary report from the Tecumseh Community Health Study. Amer. J. Epid., 1970, 9J: 233–237.—Incidence rates of coronary heart disease (CHD) among men whose parents had died of CHD and of other causes, were compared in order to assess the role of familial factors in the disease. Considerable differences were found for younger men (aged 40–59). Fatal CHD was commonest when parental death from CHD occurred before 65, and rarest when due to other causes. Non-fatal CHD was more common when parental death from CHD occurred after 65 than when it occurred prior to this age. By contrast, no appreciable differences were detected for older subjects (aged 60 and over), it is concluded that familial factors play an important role in the development of premature CHD. Evidence indicating that this form of CHD is related to elevated levels of serum cholesterol, blood glucose and blood pressure, was also presented.

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