Synthesis and antileukemic activity of (.+-.)-20-deoxyaminocamptothecin analogues.
- 1 January 1989
- journal article
- research article
- Published by Pharmaceutical Society of Japan in CHEMICAL & PHARMACEUTICAL BULLETIN
- Vol. 37 (8) , 2253-2255
- https://doi.org/10.1248/cpb.37.2253
Abstract
The camptothecin analogues (.+-.)-7-ethyl-10-methoxy-20-deoxyaminocamptothecin (2) and (.+-.)-7-ethyl-10-hydroxy-20-deoxyaminocamptothecin .cntdot. HCl (3) were synthesized from indolizine compound 4 via Friedlander condensation to construct a pentacyclic ring system, and were tested in a P388 mouse antileukemia assay. Compounds 2 and 3 were more active and less toxic than (+)-camptothecin (1), and therefore had higher therapeutic ratios.This publication has 2 references indexed in Scilit:
- Plant antitumor agents. 25. Total synthesis and antileukemic activity of ring A substituted camptothecin analogs. Structure-activity correlationsJournal of Medicinal Chemistry, 1987
- Experiments on the synthesis of dl-camptothecin. 4. Synthesis and antileukemic activity of dl-camptothecin analoguesJournal of Medicinal Chemistry, 1976