Identification of a membrane-associated receptor for transforming growth factor type E
- 1 January 1995
- journal article
- research article
- Published by Taylor & Francis in Journal of Receptors and Signal Transduction
- Vol. 15 (5) , 747-756
- https://doi.org/10.3109/10799899509079904
Abstract
We have identified the receptor for epithelial type transforming growth factor (TGFe). TGFe, a member of the epithelin/granulin family of proteins, is present primarily in tissues of epithelial origin. It is a powerful mitogen for epithelial and fibroblastic cells. TGFe, iodinated using an immobilized glucose oxidase-lactoperoxidase method, was chemically crosslinked to receptors on membranes isolated from SW-13 adrenal carcinoma cells by the crosslinker disuccinimidyl suberate (DSS). The receptor appears to be a protein which migrates at an apparent molecular weight of approximately 170-175 kDa under reducing and nonreducing conditions in SDS-polyacrylamide gels.Keywords
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