PATHOGENESIS OF 1,2‐DIMETHYLHYDRAZINE‐INDUCED CARCINOMAS IN RAT INTESTINE

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Abstract
White male Wistar rats (74) were divided into 2 groups and given weekly s.c. injections of 30 mg 1,2-dimethylhydrazine (DMH) 2 HCl/kg body wt for 10 or 15 wk, respectively, and the histological properties and distribution of DMH-induced rat carcinomas were investigated. The carcinomas induced by DMH were classified mainly into mucin-producing and nonmucin-producing carcinomas. In the large intestine, the group treated for 15 wk had significant incidences of mucin-producing carcinomas composed mainly of cells containing intracellular mucin. Mucin-producing carcinomas consisted of poorly differentiated adenocarcinoma, signet ring cell carcinoma and mucinous carcinoma, and these often coexisted within the same tumor mass. Mucin-producing carcinomas tended to develop in the proximal colon and cecum, while nonmucin-producing carcinomas were frequent in the distal colon. This method could be a useful model for study of glycoproteins of cancer cells.