DOSE RELATED CHANGES IN TISSUE MORPHINE CONCENTRATION
- 1 January 1976
- journal article
- research article
- Vol. 13 (4) , 569-577
Abstract
Rats were injected with 63H-morphine diluted with increasing amounts of non-radiolabeled morphine. The entry of the isotope into the brain and various tissues was measured by combustion in a tissue oxidizer. The relative distribution of morphine between the blood and brain remained constant at about 5.5:1 over the range of doses studied (0.07-10.0 mg/kg). No dose related differential effects on morphine uptake were evident in central tissues, with the exception of the hypothalamus which exhibited a disproportionately greater uptake. Among the noncentral tissues, kidney and liver showed the greatest dose related increases in uptake.This publication has 3 references indexed in Scilit:
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