Muscle-specific gene expression controlled by a regulatory element lacking a MyoDl-binding site
- 26 October 1989
- journal article
- Published by Springer Nature in Nature
- Vol. 341 (6244) , 716-720
- https://doi.org/10.1038/341716a0
Abstract
Muscle-specific expression of the gene encoding the delta subunit of the acetylcholine receptor is controlled by a 54-base-pair region that does not contain a binding site for MyoD1, a protein involved in activation of the myogenic program. A MyoD1-binding site is present in the proximal promoter region of the gene encoding the delta-subunit, but is neither sufficient nor necessary for muscle-specific expression in transfected muscle cells.Keywords
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