Sex, Smoking, and Cancer: a Reappraisal

Abstract
Several studies (1–4) have reported that the relative risk of cancer in smokers, compared with nonsmokers, is greater in women than in men. These results have led to speculations about the biologic mechanisms underlying this difference, such as a molecular interaction between sex hormones and tobacco carcinogens. The news media have echoed widely such results, perhaps because anything suggesting that women and men are inherently different strikes a chord among the public.

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