The Quantitative Amino Acid Requirements of Young Women II. Valine

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Abstract
The valine requirement of 7 young women has been studied by using a semi-purified diet, reducing the intake of L-valine stepwise from 1560 to 465 to 375 mg and then increasing it to 650 mg daily, and measuring the nitrogen balance. All subjects were in nitrogen equilibrium, which is defined as the excretion being within 95 to 105% of the intake, or were storing nitrogen on a daily intake of 650 mg of valine. When the intake was reduced to 465 mg daily only 4 of the 7 subjects were in equilibrium, and when it was further reduced to 375 mg the subjects were either in negative balance or showed symptoms which may have been a result of an amino acid deficiency. In a later study, 8 other subjects maintained nitrogen equilibrium on an intake of 650 mg of valine when threonine, tryptophan, phenylalanine and leucine were also present in the semi-purified diet in similarly established minimum amounts. The lowest daily intake of valine which maintained all of the subjects in the zone of nitrogen equilibrium was 650 mg. This amount is suggested as the minimum daily requirement of valine for young women similar to those studied here.

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