Low blood dendritic cells in chronic myeloid leukaemia patients correlates with loss of CD34+/CD38– primitive haematopoietic progenitors
- 2 October 2002
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 119 (1) , 115-118
- https://doi.org/10.1046/j.1365-2141.2002.03831.x
Abstract
Myeloid and plasmacytoid dendritic cells (MDC, PDC) play a key role in the initiation of immune responses. We found a reduction of DC subsets among 20 chronic myeloid leukaemia (CML) patients in chronic phase (MDC, mean, 0.10% +/- 0.10, P = 0.02; PDC, mean, 0.11% +/- 0.08, P = 0.006 versus controls). The maintenance of blood DC correlated with the presence of high percentages of circulating CD34+/CD38- progenitors that were able to give rise in vitro to CD1a+ DC. The reduced DC numbers may contribute to leukaemia escape from immune control and restoration of DC may be a goal for CML immunotherapy.Keywords
This publication has 13 references indexed in Scilit:
- Circulating blood dendritic cells from myeloid leukemia patients display quantitative and cytogenetic abnormalities as well as functional impairmentBlood, 2001
- Plasmacytoid dendritic cells activated by influenza virus and CD40L drive a potent TH1 polarizationNature Immunology, 2000
- The Nature of the Principal Type 1 Interferon-Producing Cells in Human BloodScience, 1999
- Reciprocal Control of T Helper Cell and Dendritic Cell DifferentiationScience, 1999
- Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cellNature Medicine, 1997
- Characterization of primitive subpopulations of normal and leukemic cells present in the blood of patients with newly diagnosed as well as established chronic myeloid leukemiaBlood, 1996
- BCR/ABL-negative primitive progenitors suitable for transplantation can be selected from the marrow of most early-chronic phase but not accelerated-phase chronic myelogenous leukemia patientsBlood, 1996
- Natural killer‐cell immunodeficiency in patients with chronic myelogenous leukemia. I. Analysis of the defect using the monoclonal antibodies HNK‐1 (LEU‐7) and B73.1International Journal of Cancer, 1986