Variations in theNRAMP1Gene and Susceptibility to Tuberculosis in West Africans

Open Access

5 March 1998

journal article
research article
Published by Massachusetts Medical Society in New England Journal of Medicine

Vol. 338 (10) , 640-644
https://doi.org/10.1056/nejm199803053381002

Abstract

Genetic factors may affect the susceptibility to tuberculosis, but no specific genes governing susceptibility have been identified. In mice, natural resistance to infection with some mycobacteria is influenced by the gene for natural-resistance–associated macrophage protein 1 (Nramp1 ), but the role of the human homologue of this gene, NRAMP1, in tuberculosis is unknown. We typed polymorphisms in NRAMP1 in a case–control study of tuberculosis in the Gambia, West Africa.

Keywords

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