A COMPARISON BETWEEN THE UPTAKES OF RADIOACTIVE PERCHLORATE AND IODIDE BY RAT AND GUINEA-PIG THYROID GLANDS

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Abstract
SUMMARY: Previous studies indicated that 36Cl-labelled perchlorate is concentrated by rat and rabbit thyroid gland. However, the extent of concentration of radioactive perchlorate in the gland was much less than that of iodide. Since perchlorate itself has a marked effect on anion transport in the thyroid and the specific activity of available [36C]perchlorate is very low, the stable anion as a carrier present in the injected radioactive perchlorate solution may affect the uptake of this radioactive compound by the gland. In this study, radioactive solutions of perchlorate and iodide containing different amounts of stable perchlorate or iodide (dosages ranged from 0·005 to 5 m-equiv./kg. body weight) were injected into groups of rats and guineapigs, and the thyroid: plasma concentration ratios of radioactive perchlorate and iodide were calculated and compared. These experiments were also repeated in animals pretreated with thyroid-stimulating hormone (TSH), after chronic administration of propylthiouracil (PTU), as well as in hypophysectomized animals. At the same dose levels of perchlorate, there was no difference in thyroid: plasma concentration ratios of radioactive perchlorate and iodide in control rats and guinea-pigs or in treated ones.

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